OBJECTIVE: To review the scientific evidence about the impact of climate change and socio-environmental factors on dengue transmission, particularly in the Asia-Pacific region. METHODS: Search of the published literature on PubMed, ISI web of Knowledge and Google Scholar. Articles were included if an association between climate or socio-environmental factors and dengue transmission was assessed in any country of the Asia-Pacific region. RESULTS: Twenty-two studies met the inclusion criteria. The weight of the evidence indicates that global climate change is likely to affect the seasonal and geographical distribution of dengue fever (DF) in the Asia-Pacific region. However, empirical evidence linking DF to climate change is inconsistent across geographical locations and absent in some countries where dengue is endemic. CONCLUSION: Even though climate change may play an increasing role in the transmission of DF, no clear evidence shows that such impact has already occurred. More research is needed across countries to better understand the relationship between climate change and dengue transmission. Future research should also consider and adjust for the influence of important socio-environmental factors in the assessment of the climate change-related effects on dengue transmission.